Keep Blood Glucose Stable During Pregnancy
No matter whether you have gestational diabetes or not, studies in developmental disorders strengthens the case for maintaining stable blood glucose during pregnancy, even in pregnancies without complications.
Researchers have already treated cancer and cardiovascular disease by developing drugs that increase or decrease growth factors. Growth factors are proteins that stimulate growth and typically act as signaling molecules between cells.
Abnormalities in the number and shape of dendritic spines, the protrusions that allow communication between brain neurons have been implicated in some developmental disorders. Previous studies have found that the growth factor, BDNF (brain derived neurotrophic factor) regulates the number and shape of dendritic spines required for spatial learning and memory.
When researchers from Georgetown University Medical Centre halted the transport of BDNF to dendritic spines, it caused dendritic spine abnormalities in mice that resembled those in humans with certain developmental disorders, they also had impaired learning and memory.
BDNF plays a key role in the regulation, survival, growth and maintenance of neurons. A study in 2006 found that BDNF is released from the brain and is inhibited by high blood glucose levels, but interestingly not by high insulin levels.
We know that brain function is better when blood glucose is stable and can argue that this relationship of regulation between blood glucose and BDNF could be one of the reasons. It also strengthens the case for maintaining stable blood glucose during pregnancy whether you have gestational diabetes or not.
Researchers hope to develop drugs that will increase the transport of BDNF to treat developmental disorders.
http://www.sciencedaily.com/releases/2009/10/091020161950.htm
Hi Jeanette.
This is an interesting take on where blood glucose should be maintained, because most want to have their pregnancy go as smoothly as possible, and so this may be another variable that is taken into account to perfect the procedure.
I sometimes wonder about whether keeping blood glucose levels very stable, in pregnancy or normally, has a negative impact in that we adapt to have less ability to handle atypical high or low levels of glucose that we may have at times. It is like how you don’t want to keep a child covered in shinpads and headgear to protect them all the time, because then when they take them off they might be even more likely to heavily injure themselves.
It makes sense to this for those with diabetes, though. Thanks for the information.
Hi Armen, blood glucose can be a bit like an avalanche, it gets more and more out of control until you exercise or eat something sensible. Thanks for your comments
my sister had a hard time getting pregnant because she has this abnormality in her uterus.:~”
you won’t be able to eat any food that you want during pregnancy as some foods could be harmful to the baby, like foods that ha:”,
pregnancy is sometimes dangerous specially if there are abnormalities on the uterus and birth canal””
pregnancy is sometimes life-threatening specially if there are anomalies during child development and child birth,’”
pregancy is quite critical and also requires more of your time so that you can monitor your health progress ,”`
‘*~ I am very thankful to this topic because it really gives up to date information -’:
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